Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy
Eligible age
18+ yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
The purpose of this research is to determine whether a 16-week virtually supervised aerobic and resistance exercise program is feasible in patients receiving first-line chemotherapy after surgery for ovarian or endometrial cancer and if it will improve lower extremity function (function of the legs), lessen chemotherapy-induced peripheral neuropathy (CIPN; numbness or tingling in the hands or feet), and if there is any effect on inflammatory blood markers (the level of a certain marker in the blood that is associated with inflammation; redness and swelling).
Sponsor: Dana-Farber Cancer Institute
You may qualify if…
- ✓ Newly diagnosed patients with stages III-IV ovarian or endometrial cancer
- ✓ Receiving first-line carboplatin and paclitaxel chemotherapy after surgery
- ✓ ≥18 years, children under the age of 18 will be excluded due to rarity of disease
- ✓ Physician's clearance to participate in moderate-vigorous intensity exercise
- ✓ Able to read, write, and understand English
- ✓ Ability to understand and the willingness to sign an informed consent document
- ✓ Willing to undergo two venous blood draws for the study
You may not qualify if…
- ✕ Pre-existing musculoskeletal, neurological, or cardiorespiratory conditions, as determined by the treating oncologist
- ✕ Participants with uncontrolled intercurrent illness, as determined by the treating oncologist
- ✕ Participants with psychiatric illness/social situations that would limit compliance with study requirements, as determined by the treating oncologist
- ✕ Participants who have received prior chemotherapy for cancer treatment (e.g. taxanes for breast cancer)
Where it's recruiting
Boston
Source: ClinicalTrials.gov · NCT04997096 · last updated 2026-02-19