RecruitingPatellofemoral Osteoarthritis

PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT

Eligible age

30–65 yrs

Accepts

All genders

Locations

0 states

Healthy volunteers

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About this study

The aim of the study is to compare the 12-month clinical outcomes of patients with patellofemoral osteoarthritis undergoing infiltrative treatment with fresh PRP and HA

Sponsor: Istituto Ortopedico Rizzoli

You may qualify if…

✓ 1. Age between 30 and 65;
✓ 2. Signs and symptoms of isolated patellofemoral osteoarthritis present in one or both knees;
✓ 3. Radiographic signs of isolated patellofemoral osteoarthritis (according to Iwano et al stage 1-3 classification) or chondropathy (assessed on MRI) with K-L grade of the other compartments ≤ 2. \[PMID: 2302884 - PMID: 27979409\] ;
✓ 4. Hemoglobin \> 11 g/dl; Platelet count \> 150,000 plt/mm3 (Recently performed CBC exam);
✓ 5. No clinically significant electrocardiographic alterations (Recently performed ECG).
✓ 6. Ability and consent of patients to actively participate in clinical follow-up;
✓ 7. Signature of informed consent.

You may not qualify if…

✕ 1. Patients unable to express consent;
✕ 2. Patients who have undergone intra-articular infiltration of another substance within the previous 6 months;
✕ 3. Patients undergoing knee surgery within the previous 12 months;
✕ 4. Patients with malignant neoplasms;
✕ 5. Patients with rheumatic diseases;
✕ 6. Patients with diabetes;
✕ 7. Patients with hematologic diseases (coagulopathies);
✕ 8. Patients on anticoagulant-antiaggregant therapy;

Source: ClinicalTrials.gov · NCT04937998 · last updated 2025-12-04