RecruitingMild Cognitive Impairment
Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
Eligible age
60–95 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.
Sponsor: Johns Hopkins University
You may qualify if…
- ✓ MCI defined by Clinical Dementia Rating (CDR) of 0.5 or 1.0.
- ✓ Memory, processing speed, executive function, language - cognitive scores \> 1.5 standard deviations below age-education norms.
- ✓ Not demented by history.
- ✓ Not taking statins currently or in the last 6 months.
- ✓ Cognitive/functional impairment not likely due to another neurological disease or delirium.
You may not qualify if…
- ✕ Taking a statin currently or have taken a statin in the last 6 months.
- ✕ Contraindications to taking a statin.
- ✕ Transplant patient taking cyclosporine.
- ✕ Unable to undergo MRI procedures (such as having an implanted pacemaker or defibrillator or stimulator or having non MRI compatible metal).
- ✕ Diagnosis of dementia by history.
- ✕ Current diagnosis of substance abuse.
- ✕ History of stroke or myocardial infarction in past 6 months.
- ✕ History of HIV.
Where it's recruiting
Maryland
Baltimore
Source: ClinicalTrials.gov · NCT04765137 · last updated 2025-08-06