RecruitingSleep Apnea, Obstructive
Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea
Eligible age
30–75 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between symptom phenotypes.
Sponsor: Ohio State University
You may qualify if…
- ✓ 30 to 75 years of age
- ✓ Among patients with hypertension, no change in BP medication for at least 3 months.
- ✓ Willing and able to give informed consent
- ✓ Willing and able to complete ambulatory blood pressure monitoring at baseline and after 6-months.
- ✓ Sleep study \[Polysomnography (PSG) or Home Sleep Apnea Study (HSAT) performed based on clinical grounds
- ✓ 4% oxygen desaturation index (ODI4) ≥15 events/hour on clinical sleep study
- ✓ Planned CPAP treatment by treating provider
You may not qualify if…
- ✕ Unable to apply BP cuff (e.g. arm circumference \>55 cm, prior breast cancer, structural abnormalities of the arm)
- ✕ Current use of CPAP or Dental Device for OSA
- ✕ Category III-IV of heart failure
- ✕ Presence of Cheyne-Stokes Respiration (CSR) in PSG
- ✕ Predominantly central sleep apnea (AHI≥15 events/hour)
- ✕ Pregnancy
- ✕ History of renal failure, or renal transplant
- ✕ Self-reported sleep duration less than 5 hours per night on weeknights (work nights)
Where it's recruiting
Ohio
Columbus
Source: ClinicalTrials.gov · NCT04712656 · last updated 2025-07-24