Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms
Eligible age
18–85 yrs
Accepts
All genders
Locations
5 states
Healthy volunteers
Yes
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About this study
The overall objective of this study is to determine if there are pyloric sphincter abnormalities in patients with gastroparesis symptoms and determine how prevalent these abnormalities are using tests to assess the pyloric sphincter - endoluminal functional luminal imaging probe (Endoflip™), water load satiety testing (WLST), and high-resolution cutaneous electrogastrography (HR-EGG) using Gastric Alimetry™ System.
Sponsor: Johns Hopkins Bloomberg School of Public Health
You may qualify if…
- ✓ 1. Provision of signed and dated informed consent form.
- ✓ 2. Stated willingness to comply with all study procedures and availability for the duration of the study.
- ✓ 3. Male or female, aged 18-85
- ✓ 4. Symptoms of gastroparesis, either diabetic or idiopathic etiology
- ✓ 5. Symptoms of gastroparesis with minimum Gastroparesis Cardinal Symptom Index (GCSI) score of 2.0
- ✓ 6. Individual will have had a prior 4-hour gastric emptying scintigraphy test performed for clinical evaluation within the last 6 months. This gastric emptying test would be done for clinical evaluation and is not part of the research study. From these participants with gastroparesis symptoms, we will include those with delayed gastric emptying as well as those with normal gastric emptying.
- ✓ 7. Participant must not initiate any new treatments until completion of the study procedures.
- ✓ 8. Willingness to:
You may not qualify if…
- ✕ 1. Prior gut lumen surgery on the esophagus or the stomach, including Nissen fundoplication.
- ✕ 2. Prior surgery on the pylorus (G-POEM, surgical pyloroplasty, surgical pyloromyotomy)
- ✕ 3. Known history of achalasia or esophageal stricture
- ✕ 4. Known history of physiological or mechanical GI obstruction
- ✕ 5. Abnormalities seen on a prior upper endoscopy placing patient at increased risk:
- ✕ Ulcer of the esophagus, stomach, or duodenum
- ✕ Esophageal varices
- ✕ 6. Individuals at risk for prolonging the endoscopy procedure: severe chronic pulmonary disease, severe food retention in the stomach on endoscopy.
Where it's recruiting
Scottsdale
Louisville
Boston
Winston-Salem
Philadelphia
Source: ClinicalTrials.gov · NCT04661215 · last updated 2026-04-03