University of Iowa Interventional Psychiatry Service Patient Registry
Eligible age
18–99 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. "fight-or-flight" response). The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient ("personalized medicine").
Sponsor: Mark Niciu
You may qualify if…
- ✓ 1. 18-99 years of age
- ✓ 2. English-speaker with a level of understanding sufficient to agree to clinical treatment with a treatment modality offered by the Interventional Psychiatry Service, all required research procedures, and sign an informed consent document
- ✓ 3. Clinical diagnosis of a major depressive episode in the context of major depressive disorder or bipolar disorder or treatment-resistant OCD evaluated by a provider on the Interventional Psychiatry Service and felt to be an appropriate candidate for clinical treatment with a treatment modality offered by the Interventional Psychiatry Service.
You may not qualify if…
- ✕ 1. Age less than 18 years
- ✕ 2. A primary neuropsychiatric diagnosis that is not either major depressive disorder or bipolar disorder
- ✕ 3. Serious, unstable medical conditions/problems including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, or hematologic disease, e.g. uncontrolled asthma, uncontrolled hyper/hypothyroidism or active cancer.
- ✕ 4. Involuntary commitment to psychiatry inpatient units
- ✕ 5. If patients have one or more of the following MRI Exclusion criteria, they will not be able to participate in those aspects of this study:
- ✕ 1. The presence of an implanted device including pacemaker, coronary stent, defibrillator, or neurostimulation device that is not MRI-compatible
- ✕ 2. The presence of ferromagnetic objects in the body, i.e. bullets, shrapnel, and/or metal slivers
- ✕ 3. Clinically-significant claustrophobia
Where it's recruiting
Iowa City
Source: ClinicalTrials.gov · NCT04480918 · last updated 2026-03-03