RecruitingPreeclampsia Postpartum
Aspirin and Preeclampsia
Eligible age
18–45 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.
Sponsor: University of Chicago
You may qualify if…
- ✓ 1. Pregnant Adults between 18 and 45 years of age
- ✓ 2. Diagnosed with preeclampsia
- ✓ 3. Presenting for delivery with a singleton gestation.
You may not qualify if…
- ✕ 1. We will exclude patients in labor
- ✕ 2. Patients with preexisting cardiomyopathy, chronic hypertension, ischemic or valvular heart disease, pulmonary disease, diabetes mellitus, chronic kidney disease, multiple gestation
- ✕ 3. Plan to deliver outside of the participating site
- ✕ 4. Co-enrolled in other trials that might affect the patients taking the study medication, as determined by the PI.
- ✕ 5. Aspirin allergy
- ✕ 6. Clear indication for aspirin therapy or contraindication to aspirin therapy
- ✕ 7. Clinically significant conditions that might limit adherence to trial regimen (e.g., peptic ulcer disease, history of gastrointestinal bleeds, bleeding disorders)
- ✕ 8. Currently or planning on taking any nonsteroidal anti-inflammatory drugs while they are participating in this study.
Where it's recruiting
Illinois
Chicago
Source: ClinicalTrials.gov · NCT04479072 · last updated 2026-05-04