Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial
Eligible age
35–99 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
No
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About this study
Cooled radiofrequency ablation (cRFA) of the knee geniculate nerves is a promising treatment option for knee osteoarthritis, but has variable efficacy. Fluoroscopy is the typical guidance of choice, but uses bony landmarks to target these nerves which have variable positions around the knee. Alternatively, ultrasound allows for targeting based on visualization of bony landmarks, the nerves, and their accompanying vascular structures, and thus may offer greater accuracy. However, there are few studies which directly compare the clinical efficacy of these two guidance options. This study will compare these two options.
Sponsor: University of California, Davis
You may qualify if…
- ✓ 1\) patients of either gender with primary knee OA of one or both knees fulfilling the diagnostic criteria for knee OA by the American College of Rheumatology,
- ✓ 2\) Kellgren-Lawrence score of two to four,
- ✓ 3\) reported NPRS pain intensity of at least four on most or all days of the past week
- ✓ 4\) pain resistant to conventional treatments which may include but is not limited to medications (e.g. acetaminophen, oral or topical non-steroidal anti-inflammatory drugs, opioids), physical therapy, and intra-articular injections (e.g. corticosteroids, hyaluronic acid, platelet-rich-plasma) for at least 3 months. In the case of bilateral knee OA, the most symptomatic knee will be treated and studied.
You may not qualify if…
- ✕ 1\) age \<35 years,
- ✕ 2\) non-English speaking patients,
- ✕ 3\) body mass index greater than 40,
- ✕ 4\) previous radiofrequency ablation procedure for the knee,
- ✕ 5\) active systemic or local infections at the site of needle/cRFA probe placement,
- ✕ 6\) previous knee joint replacement surgery,
- ✕ 7\) autoimmune or inflammatory cause of knee arthritis such as rheumatoid or psoriatic arthritis,
- ✕ 8\) non-ambulatory patients,
Where it's recruiting
Sacramento
Rochester
Source: ClinicalTrials.gov · NCT04472702 · last updated 2026-06-16