RecruitingCognitive Impairment, MildDementiaCardiovascular Diseases

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Eligible age

75+ yrs

Accepts

All genders

Locations

35 states

Healthy volunteers

Yes

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About this study

PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.

Sponsor: Duke University

You may qualify if…

✓ Community-dwelling adults
✓ Age ≥75 years
✓ English or Spanish as primary language
✓ Able to provide a trusted contact

You may not qualify if…

✕ Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
✕ Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
✕ Dementia (clinically evident or previously diagnosed)
✕ Dependence in any Katz Basic Activities of Daily Living \[ADL\] (with the exception of urinary or bowel continence)
✕ Severe hearing impairment (preventing phone follow up)
✕ Unable to talk (preventing phone follow up)
✕ Statin use in the past year or for longer than 5 years previously (participant reported)
✕ Ineligible to take atorvastatin 40 mg (clinician determined)