Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
Eligible age
60+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Obstructive sleep apnea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are highly prevalent chronic respiratory diseases in the Veteran population. OSA co-occurring with COPD, known as Overlap Syndrome (OVS), is a complex chronic medical condition associated with grave consequences. OVS is highly prevalent in Veterans. Veterans with OVS may be at increased risk for cognitive deficits, poor sleep quality as well as a reduced quality of life (QoL). The overall objective is to study the effects of positive airway pressure therapy on clinical outcomes in patients with OVS.
Sponsor: VA Office of Research and Development
You may qualify if…
- ✓ OSA with moderate-to-severe disease, AHI 20 per hour by in-lab polysomnography with concomitant moderate-severe COPD based on pulmonary function tests (PFTS) and with past significant history (\>10 pack-years) of smoking
- ✓ Male or female gender
- ✓ Age greater than or equal to 60 years
- ✓ Stable treatment regimen for COPD
You may not qualify if…
- ✕ Current or prior treatment with PAP or oral appliance
- ✕ Central sleep apnea defined as central apnea index \>5 per hour and comprising 50% of AHI
- ✕ Known primary neuromuscular diseases
- ✕ Disorders that may impact cognitive function including:
- ✕ neurodegenerative disorders
- ✕ traumatic brain injury
- ✕ untreated PTSD and/or history of learning disability
- ✕ Medicines that may cause or alter sleepiness: sedative hypnotics, or stimulants as these may alter the results
Where it's recruiting
Detroit
Source: ClinicalTrials.gov · NCT04179981 · last updated 2026-06-05