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RecruitingMetabolic SyndromeMetabolic Syndrome, Protection AgainstGlucose Metabolism Disorders

Animal and Plant Proteins and Glucose Metabolism

Eligible age

21–70 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.

Sponsor: University of Missouri-Columbia

You may qualify if…

  • ✓ age: ≥21 and ≤70 years;
  • ✓ BMI: \>24.5 and \<32.5 kg/m2;
  • ✓ habitual protein intake \<0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and
  • ✓ weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study.

You may not qualify if…

  • ✕ prediabetes or type 2 diabetes;
  • ✕ evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate \<60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g);
  • ✕ vegetarians or vegans;
  • ✕ intolerance or allergies to ingredients in the metabolic meal or intervention diet;
  • ✕ take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcomes;
  • ✕ received antibiotic or antifungal treatment (which affect the microbiome and therefore microbial metabolite production) 2 months before entering the study;
  • ✕ consume tobacco products or excessive alcohol (women: \>14 drinks/week; men: \>21 drinks/week);
  • ✕ evidence of significant organ system dysfunction or diseases (e.g., cirrhosis), and

Where it's recruiting

Missouri

Columbia

Source: ClinicalTrials.gov · NCT03994367 · last updated 2026-05-08

Animal and Plant Proteins and Glucose Metabolism · TrialPath