Blood Donor CVD 5000
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This is an open-label, non-randomized study. Volunteers will be vaccinated with the typhoid oral vaccine, Vivotif. Vivotif has been licensed by the Food and Drug Administration (FDA) for travelers to developing countries. Volunteers will also be asked to provide blood, saliva, and stool specimens over a follow-up time period of up to eight years. The specimens obtained in this clinical research study will be used to further the investigator's understanding of the protective immunological mechanisms that can be elicited systemically and may be applicable to other enteric pathogens.
Sponsor: University of Maryland, Baltimore
You may qualify if…
- ✓ Age 18 years and older
- ✓ Good general health as determined by a screening evaluation within 28 days before blood donation
- ✓ Informed, written consent
You may not qualify if…
- ✕ History of any of the following medical illnesses:
- ✕ Diabetes
- ✕ Cancer in past 5 years (except for basal cell carcinoma of the skin and cervical carcinoma in situ)
- ✕ Heart disease (Hospitalization for a heart attack, coronary artery bypass graft, arrhythmia, or syncope, within past 5 years. Current symptoms of heart disease - dyspnea, angina, orthopnea)
- ✕ Recurrent infections (more than 3 hospitalizations for invasive bacterial infections such as pneumonia or meningitis)
- ✕ Current drug or alcohol abuse
- ✕ Active ulcer disease or ongoing intestinal condition
- ✕ Treatment for anemia in last 6 months
Where it's recruiting
Baltimore
Source: ClinicalTrials.gov · NCT03971669 · last updated 2026-03-27