RecruitingObesity, Morbid
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.
Sponsor: Mayo Clinic
You may qualify if…
- ✓ BMI 40 - 50 kg/m2.
- ✓ Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery
You may not qualify if…
- ✕ Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL
- ✕ Active coronary artery disease
- ✕ Participation in structured exercise (\>2 times per week for 30 minutes or longer)
- ✕ Smoking
- ✕ Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids)
- ✕ Renal insufficiency (serum creatinine \> 1.5mg/dl)
- ✕ Chronic active liver disease (Bilirubin \> 17mmol/L, AST \> 144 IU/L, or ALT\>165IU/L)
- ✕ Pregnancy or breastfeeding.
Where it's recruiting
Minnesota
Rochester
Source: ClinicalTrials.gov · NCT03868592 · last updated 2026-03-03