Accelerated iTBS for Post Partum Depression
Eligible age
18–50 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
Study 1: The investigators are studying the feasibility and tolerability of 10x/day intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over the course of 6 days for women with post-partum depression. The investigators further aim to characterize the anticipated anti-depressant effect of this treatment paradigm. Study 2: The investigators are studying the feasibility and tolerability of 12 sessions/day of intermittent theta burse (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over 5 days for women with post-partum depression. The investigators aim to compare the two different treatment schedules.
Sponsor: Medical University of South Carolina
You may qualify if…
- ✓ 1. Participants must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments.
- ✓ 2. Participants must be over the age of 18.
- ✓ 3. Participants must meet criteria for post-partum depression: a) onset of symptoms in the first year postpartum
- ✓ 4. Participants must have a HRSD17 greater than or equal to 14 at baseline.
You may not qualify if…
- ✕ 1. Participants must not be pregnant.
- ✕ 2. Participants must not meet moderate or severe use disorder of any substance with the exception of Tobacco Use Disorder.
- ✕ 3. Participants must not have current psychotic symptoms.
- ✕ 4. Participants must not have a history of dementia or other cognitive impairment.
- ✕ 5. Participants must not have active suicidal ideation requiring hospitalization or a suicide attempt within the past 3 months.
- ✕ 6. Participants must not have any contraindications to receiving rTMS (e.g. metal implanted above the neck, history of seizure, any known brain lesion).
- ✕ 7. Participants must not have any unstable general medical conditions.
- ✕ 8. Participants must not have had eclampsia during pregnancy.
Where it's recruiting
Charleston
Source: ClinicalTrials.gov · NCT03417960 · last updated 2026-05-22