RecruitingChronic Obstructive Pulmonary Disease
Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.
Sponsor: University of Virginia
You may qualify if…
- ✓ Subjects must have a diagnosis of COPD
- ✓ at their clinical baseline on the day of imaging
- ✓ must be clinically stable in order to participate in the study.
- ✓ COPD subjects will be categorized according to the GOLD
- ✓ Current/Former SmokerSubjects
- ✓ must have a smoking history ≥ 10 pack years
You may not qualify if…
- ✕ Dx of asthma
- ✕ Continuous oxygen use at home
- ✕ Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging
- ✕ FEV1 percent predicted less than 25%
- ✕ Pregnancy or lactation
- ✕ Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning
- ✕ Subjects with any implanted device that cannot be verified as MRI compliant will be excluded
- ✕ Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches
Where it's recruiting
Virginia
Charlottesville
Source: ClinicalTrials.gov · NCT03331302 · last updated 2020-11-04