RecruitingAlcoholic Liver Disease
Ethanol Induces Skeletal Muscle Autophagy
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.
Sponsor: The Cleveland Clinic
You may qualify if…
- ✓ Alcoholic liver disease:
- ✓ clinical, biochemical, imaging criteria and liver biopsy where available
- ✓ Age 18 - 65 years old
- ✓ Controls:
- ✓ Serum liver transaminases (i.e. ALT and AST) 40 IU/L
- ✓ Normal liver ultrasound
- ✓ Age 18 - 65 years old
You may not qualify if…
- ✕ For both groups - alcoholic liver disease and controls:
- ✕ Poorly controlled diabetes mellitus (HbA1C\>9.5 g/dl)
- ✕ Untreated Hyper- / hypo- thyroidism
- ✕ Patients on dialysis, renal disease with serum creatinine 1.5 mg/dL
- ✕ Active intravenous drug use
- ✕ History of bowel surgery or gastric bypass surgery
- ✕ Medications known to alter muscle protein metabolism (i.e. corticosteroids, tamoxifen, high-dose estrogen, testosterone or anabolic steroids)
- ✕ Metastatic disease, Advanced cardiac or pulmonary disease
Where it's recruiting
Ohio
Cleveland
Source: ClinicalTrials.gov · NCT03209791 · last updated 2026-01-09