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RecruitingSpinal Cord InjuriesParaplegia, Complete

Epidural Stimulation After Neurologic Damage

Eligible age

22+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement. The study will also characterize improvement in autonomic function (such as blood pressure control) and other functions related to spinal cord injury.

Sponsor: University of Minnesota

You may qualify if…

  • ✓ 22 years of age or older
  • ✓ Able to undergo the informed consent/assent process
  • ✓ Stable, motor-complete paraplegia
  • ✓ Discrete spinal cord injury between C6 and T10
  • ✓ ASIA A or B Spinal Cord Injury Classification
  • ✓ Medically stable in the judgement of the principal investigator
  • ✓ Intact segmental reflexes below the lesion of injury
  • ✓ Greater than 1 year since initial injury and at least 6 months from any required spinal instrumentation

You may not qualify if…

  • ✕ Diseases and conditions that would increase the morbidity and mortality of spinal cord injury surgery (e.g. cardiopulmonary issues)
  • ✕ Inability to withhold antiplatelet/anticoagulation agents perioperatively
  • ✕ Significant dysautonomia that would prohibit rehabilitation or assisted standing or any history of CVA or MI associated with autonomic dysreflexia. A single tilt table test with syncope, presyncope, or SBP \< 50 or \>200.
  • ✕ Other conditions that would make the subject unable to participate in testing/rehabilitation in the judgement of the principal investigator
  • ✕ Current and anticipated need for opioid pain medications or pain that would prevent full participation in the rehabilitation program in the judgement of the principal investigator
  • ✕ Clinically significant mental illness in the judgement of the principal investigator
  • ✕ Botulinum toxin injections in the previous 6 months
  • ✕ Volitional movements present during EMG testing in bilateral lower extremities

Where it's recruiting

Minnesota

Minneapolis

Source: ClinicalTrials.gov · NCT03026816 · last updated 2026-04-08

Epidural Stimulation After Neurologic Damage · TrialPath