RecruitingDiabetes
Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye
Eligible age
18–75 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The intervention in this trial is intraocular islet transplantation. A single dose of 1000 - 3000 Islet Equivalents (IEQ)/kg recipient body weight (BW) will be infused into the anterior chamber of the eye through a self-sealing incision in the peripheral cornea. The procedure is projected to take approximately 20-30 minutes. Transplant recipients in this study will receive localized maintenance immunosuppression via topical application of eye-drops.
Sponsor: Midhat H. Abdulreda
You may not qualify if…
- ✕ Ophthalmic exclusion criteria (only in surgical eye):
- ✕ 1. Poor visualization of the anterior chamber (corneal opacity, corneal edema, Herpes Keratitis).
- ✕ 2. Aphakic status (no lens).
- ✕ 3. Narrow angle of iris anatomy: Spade Scale IV.
- ✕ 4. History of uncontrolled glaucoma or glaucoma that had required surgical intervention (e.g., trabeculectomy or shunting devices).
- ✕ 5. Active uncontrolled uveitis.
- ✕ 6. Presence of silicone in the anterior segment after complex diabetic retinopathy surgery.
- ✕ 7. History of allergy to topical steroids and immune-modulatory drugs including CSA and Tacrolimus.
Where it's recruiting
Florida
Miami
Source: ClinicalTrials.gov · NCT02846571 · last updated 2026-03-12