Sleep Apnea in Elderly
Eligible age
60–89 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
Sleep-disordered breathing (SDB or sleep apnea) is very common among elderly Veterans and leads to increased morbidity and mortality in this population. The proposal aims to identity whether oxygen, finasteride and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in the elderly via different mechanisms. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea in the elderly. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea. A cumulative effect of the investigators' research will fulfill the long-term goal of improving the quality of life of elderly Veterans suffering from sleep apnea and its potential life-threatening complications.
Sponsor: VA Office of Research and Development
You may qualify if…
- ✓ Adults with mild to moderate sleep apnea with Apnea-Hypopnea Index (AHI)\>/=5 to 20/hour with central, obstructive, mixed apneas and hypopneas
- ✓ For the finasteride protocol elderly men with above criteria will be enrolled
You may not qualify if…
- ✕ Patients with severe sleep apnea (Apnea-Hypopnea Index (AHI)\>20/hour)
- ✕ Patients with history of prostate cancer
- ✕ Males with hypogonadism
- ✕ History of cardiac disease, including myocardial infarction
- ✕ Bypass surgery
- ✕ Atrial and ventricular tachy-bradycardias
- ✕ Systolic congestive heart failure and Cheyne-Stokes respiration
- ✕ Current unstable angina
Where it's recruiting
Detroit
Source: ClinicalTrials.gov · NCT02703220 · last updated 2026-08-21