RecruitingNeuroblastoma

Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

Eligible age

Up to 22 yrs

Accepts

All genders

Locations

19 states

Healthy volunteers

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About this study

A prospective open label, multicenter study to evaluate the feasibility and acute toxicity of using molecularly guided therapy in combination with standard therapy followed by a Randomized Controlled Trial of standard immunotherapy with or without DFMO followed by DFMO maintenance for Newly Diagnosed High-Risk Neuroblastoma.

Sponsor: Giselle Sholler

You may not qualify if…

✕ 1. Participants who are 12-18 months of age with INSS Stage 4 and all stage 3 participants with favorable biologic features (ie, nonamplified MYCN, favorable pathology, and DNA index \> 1) are not eligible.
✕ 2. Lactating females are not eligible unless they have agreed not to breastfeed their infants.
✕ 3. Participants receiving any investigational drug concurrently.
✕ 4. Participants with any other medical condition, including but not limited to malabsorption syndromes, mental illness or substance abuse, deemed by the Investigator to be likely to interfere with the interpretation of the results or which would interfere with a participant's ability to sign or the legal guardian's ability to sign the informed consent, and participant's ability to cooperate and participate in the study