RecruitingSpinal Cord InjuriesSpinal Cord Injury at C5-C7 LevelSpinal Cord Injury Cervical
Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury
Eligible age
17+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
This study is to evaluate the use of a fully implanted device for providing hand function, reach, and trunk function to individuals with cervical spinal cord injury. Funding Sources: FDA OOPD NIH NINDS
Sponsor: Anne Bryden
You may qualify if…
- ✓ Diagnosis of cervical level spinal cord injury, either complete or incomplete; International Standards for Neurological Classification of Spinal Cord Injury (INCSCI) motor level of C4 through C8; American Spinal Injury Impairment Scale (AIS) grade A, B, C, or D; six months or more post-injury
- ✓ Biceps/brachialis/brachioradialis strength of 2/5 or higher on Manual Muscle Test
- ✓ Peripheral nerve innervation to upper extremity and trunk muscles, including a grade 3/5 or higher stimulated strength (Manual Muscle Test) in at least two of the following muscles in one arm: adductor pollicis, abductor pollicis brevis, flexor pollicis longus, extensor pollicis longus, extensor digitorum communis, flexor digitorum superficialis, flexor digitorum profundus, pronator quadratus, extensor carpi ulnaris, extensor carpi radialis brevis, extensor radialis longus, flexor carpi ulnaris, flexor carpi radialis, first dorsal interosseous; and in at least two of the following muscles: left/right gluteus maximus, left/right erector spinae, left/right quadratus lumborum,
- ✓ Age \> 16 years
- ✓ Medically stable - cleared for surgery
- ✓ Able and willing to take part in study
You may not qualify if…
- ✕ Currently pregnant (neuroprosthesis implantation delayed until no longer pregnant)
- ✕ Other neurological conditions (multiple sclerosis, diabetes with peripheral nerve involvement)
- ✕ History of coagulopathy, HIV, severe cardiopulmonary disease, severe bradycardia, severe autonomic dysreflexia, or chronic obstructive pulmonary disease.
- ✕ Active untreated infection such as decubitus ulcer, urinary tract infection, pneumonia
- ✕ Presence of other active implantable medical devices with unknown or untested interaction with the NNP implant
- ✕ Active implantable medical device (AIMD) such as a pacemaker or defibrillator, with the exception of the implanted stimulator-telemeter (IST) or implanted receiver stimulator (IRS) systems developed by the Cleveland Functional Electrical Stimulation Center
- ✕ Unhealed fractures that prevent functional use of arm or trunk
- ✕ Less than six months post-injury (neuroprosthesis implantation delayed until criteria met)
Where it's recruiting
Ohio
Cleveland
Source: ClinicalTrials.gov · NCT02329652 · last updated 2025-12-19