Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development
Eligible age
Up to 20 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the heart beats. Investigators will also study the proteins and RNA of these pieces to determine how the newborn heart cells control their force of contraction differently from adult heart cells. Investigators hypothesize that infant hearts have different regulation of calcium entry than adult hearts. The study team also wants to study combinations of 3D cardiac spheres with multiple environmental cues that can improve functional and metabolic maturation of Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and generate a more clinically relevant cell model.
Sponsor: Emory University
You may qualify if…
- ✓ Patients undergoing cardiopulmonary bypass surgery
- ✓ Patients undergoing surgery for repair of congenital heart disease such as ventricular septal defect or defective mitral or aortic valves.
You may not qualify if…
- ✕ Prior cardiac surgery
- ✕ History of atrial fibrillation or other atrial arrhythmias prior to operation
- ✕ History of heart failure
Where it's recruiting
Atlanta
Source: ClinicalTrials.gov · NCT00243776 · last updated 2026-05-06